解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The possible irreversible blockade of 5-hydroxytryptamine1 receptor subtypes 5-hydroxytryptamine1A, 5-hydroxytryptamine1B/5-hydroxytryptamine1D and 5-hydroxytryptamine1C by the chloramine 8-methoxy-2-(N-2'-chloropropyl,N-propyl)aminotetralin (8-MeO-2'-chloro-PAT) was investigated in rat brain sections by quantitative ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90436-3
更新日期:1989-01-01 00:00:00
abstract::The cerebellum receives input from visual cortical areas via a relay in the pontine nuclei. We have compared the location in the pontine nuclei of terminal fields of fibres from visual areas 18 and 20, and the posteromedial lateral suprasylvian visual area. Due to individual variations in the precise location of termi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90335-7
更新日期:1989-01-01 00:00:00
abstract::The 2-deoxyglucose metabolic mapping technique has been used to investigate the neural mechanisms which underlie the symptoms of Parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease. In six cynomolgus monkeys, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was either (a) ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90120-6
更新日期:1989-01-01 00:00:00
abstract::Adrenergic neurons in the C1 region in the ventrolateral medulla oblongata send descending axons into spinal cord which terminate in thoracic and upper lumbar segments, overlapping the distribution of sympathetic preganglionic neurons. The present study was undertaken to determine whether adrenergic fibers synapse dir...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90099-7
更新日期:1989-01-01 00:00:00
abstract::The activity of 62 antidromically identified prepositus hypoglossi neurons was recorded in 10 alert cats during spontaneous, vestibular or visually induced eye movements. Neurons were antidromically activated from stimulating electrodes implanted in the ipsilateral medial longitudinal fasciculus (n = 24), the ipsilate...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90058-4
更新日期:1989-01-01 00:00:00
abstract::Origins and pathways of cerebrovascular substance P- and calcitonin gene-related peptide-positive nerves in rat were studied by immunohistochemistry combined with denervation experiments and retrograde axonal tracer technique. The two peptides have been found to coexist in one and the same neuron. After sectioning of ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90385-0
更新日期:1989-01-01 00:00:00
abstract::Characteristics of atrial natriuretic peptide receptors were determined in cultured mouse spinal cord cells. Saturation and competition experiments demonstrated the presence of a single class of atrial natriuretic peptide binding sites with high affinity (KD = 0.054 nM) and a density of 1.92 fmoles/10(6) cells. A simi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90342-4
更新日期:1989-01-01 00:00:00
abstract::The rat neurohypophysis contains a population of microglial cells, the majority of which occupy a pericapillary position in the resting gland. The microglia are immunocytochemically identifiable by the presence of macrophage-associated antigens and resemble microglia of the CNS. Morphometry at light and electron micro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90409-0
更新日期:1989-01-01 00:00:00
abstract::The acute behavioural and metabolic consequences of functional changes following unilateral intracaudate kainic acid at the level of the feline caudate nucleus, the substantia nigra pars reticulata and the deeper layers of the colliculus superior were investigated. The present study became possible since it was previo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90240-6
更新日期:1989-01-01 00:00:00
abstract::Intracellular recordings were performed from projection cells of the cat dorsal lateral geniculate nucleus in vitro to investigate the properties and origin of optic tract evoked inhibitory postsynaptic potentials mediated by GABAB receptors and their relationship to the physiologically different cell classes present ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90307-2
更新日期:1989-01-01 00:00:00
abstract::The development of the catecholaminergic system in the hypothalamus and in the septal region was studied in rats from the 12th fetal day until the 9th postnatal day. Catecholaminergic structures were visualized with pre-embedding immunocytochemistry using antiserum to tyrosine hydroxylase. An intensification of diamin...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90338-2
更新日期:1989-01-01 00:00:00
abstract::The afferent inputs to the rostral pole of the anterior pretectal nucleus have been examined by utilizing the retrograde axonal transport of a fluorescent dye, Fast Blue. After unilateral injection of the dye into the rostral anterior prectectal nucleus, large numbers of labelled neuronal somata were found in the soma...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90141-3
更新日期:1989-01-01 00:00:00
abstract::The unilateral application of GABA (10(-5) M; 30 min) into thalamic motor nuclei of the cat increases the release of dopamine in both caudate nuclei. This effect has been suggested to be related to an activation of the bilateral corticostriatal glutamatergic projection, glutamate exerting a presynaptic facilitatory in...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90183-8
更新日期:1989-01-01 00:00:00
abstract::Phospholipids and cholesterol were found to be the main lipids in mature and immature neuroblastoma cells. The ratios for the total cholesterol/phospholipids in these undifferentiated and differentiated cells were 0.33 and 0.52, respectively. The ratios of 0.45 and 0.62 were obtained with corresponding plasma membrane...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90361-8
更新日期:1989-01-01 00:00:00
abstract::In vitro autoradiography was used to examine the N-methyl-D-aspartate receptor in the brain of a baboon species, Papio anubis, and compared to that of Papio papio which exhibits a photosensitive epilepsy. The epilepsy originates in the frontal cortex and is accompanied by an enhanced sensitivity to N-methyl-D-aspartat...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90106-1
更新日期:1989-01-01 00:00:00
abstract::Miniature endplate potentials were recorded from edge muscle fibers of frog sartorius muscles during high frequencies induced with K-propionate and during recovery. The identified neuromuscular junctions were studied with the electron microscope and their ultrastructure was correlated with amplitude and numbers of min...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90210-2
更新日期:1988-12-01 00:00:00
abstract::Monoamine storage vesicles accumulate transmitters via an active transport process which presents similar pharmacological and bioenergetic properties in all monoaminergic systems. Using [3H]reserpine, a specific ligand of the vesicular monoamine transporter on isolated storage vesicles, we have determined the molecula...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90207-2
更新日期:1988-12-01 00:00:00
abstract::Ablation of capsaicin-sensitive afferent neurons enhances experimentally induced ulceration in the rat gastric mucosa, which suggests that these neurons are involved in gastric mucosal protection. To provide direct evidence for such a function it was investigated whether stimulation of afferent nerve endings by the in...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90201-1
更新日期:1988-12-01 00:00:00
abstract::The participation of excitatory neurotransmitter systems in the basal ganglia in the initiation and propagation of limbic seizures induced by pilocarpine has been investigated in the rat. Limbic seizures (electrographic and motor) occur in rats receiving bilateral microinjections into the entopeduncular nucleus of 12....
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90187-x
更新日期:1988-12-01 00:00:00
abstract::A quantitative electron-microscopic analysis has been conducted on the neurons within the gustatory zone of the nucleus of the solitary tract of the hamster. The most common group of neurons within the gustatory zone contains both large (X1) and small (X3) members that possess deeply invaginated nuclear profiles. Thes...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90198-4
更新日期:1988-12-01 00:00:00
abstract::This paper examines the topography of neuronal degeneration in the central nervous system of the dystonia musculorum (dt) mutant mouse, revealed by selective silver impregnation, specific histochemical staining and electron microscopy. Neuronal lesions have been observed exclusively in the spinal cord, the medulla and...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90277-1
更新日期:1988-11-01 00:00:00
abstract::The distribution, structural organization and state of phosphorylation of neurofilaments have been examined in chromaffin cells from adult bovine adrenal medulla cultured under various conditions using a series of monoclonal antibodies directed against phosphorylated and nonphosphorylated epitopes of the 200,000 mol. ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90301-6
更新日期:1988-11-01 00:00:00
abstract::We have measured on-line the exocytotic secretion of ATP from adrenal medullary chromaffin cells induced by Ba2+ using a luciferin/luciferase assay. We have found that Ba2+-induced ATP release requires the entry of Ba2+ through either voltage- or receptor-gated Ca2+ channels. This conclusion is based on the observatio...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90300-4
更新日期:1988-11-01 00:00:00
abstract::The present study was undertaken to investigate the possible effects of Spantide [D-Arg1, D-Trp7,9 Leu11]-substance P, a substance P antagonist, and of somatostatin on spinal cord blood flow. The experiments were performed with the laser-doppler technique on the L1 spinal cord segment exposed by laminectomy. The effec...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90236-9
更新日期:1988-10-01 00:00:00
abstract::The distribution of axons according to diameter has been examined in the optic nerve of old world monkeys. Axon diameters were measured from electron micrographs, and histograms were constructed at regular intervals across a section through the optic nerve to reveal the local axon diameter distribution. The total axon...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90231-x
更新日期:1988-10-01 00:00:00
abstract::The pharmacological characteristics and anatomical distribution of benzodiazepine receptors in the human hippocampal formation were studied in seven cases aged 4-68 years. The pharmacology of the receptors was studied by computerized, non-linear least squares regression analysis of [3H]flunitrazepam displacement by fl...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90098-x
更新日期:1988-09-01 00:00:00
abstract::The neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamus were demonstrated by electrolytic lesion studies and fluorescent retrograde tracing combined with immunocytochemistry. Three-to-five-day-old rats were used, because the immunoreactivity of neurotensin fibers in anteri...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90102-9
更新日期:1988-09-01 00:00:00
abstract::The ontogeny of the calcitonin gene-related peptide in the neuron system of the rat brain stem was investigated by means of the indirect immunofluorescence technique. Calcitonin gene-related peptide-like immunoreactivity was first detected in the fibers of the nucleus of spinal tract trigeminal nerve on gestational da...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90108-x
更新日期:1988-09-01 00:00:00
abstract::Following injection of horseradish peroxidase-labeled wheat germ agglutinin or of rhodamine-labeled microspheres as non-selective tracers into the rat red nucleus, the origins of the corticorubral and cerebellorubral pathways, as well as a considerable number of other brain structures including dorsal raphé nucleus, z...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90168-6
更新日期:1988-08-01 00:00:00
abstract::The distribution of D1 dopamine receptors was studied autoradiographically in the basal ganglia of the cat, monkey and human. These receptor binding sites were labeled directly with the D1-selective antagonist [3H]SCH 23390, and ligand-binding assays were performed concurrently. Serial- or same-action analysis permitt...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90130-3
更新日期:1988-07-01 00:00:00
abstract::The dorsal portion of the nucleus submedius of the rat thalamus receives spinal and trigeminal projections which may convey noxious inputs. The present study was undertaken to analyse the fine structure of the nucleus with particular reference to a possible trigemino-thalamo-prefrontal cortical pathway relaying in nuc...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90133-9
更新日期:1988-07-01 00:00:00
abstract::The cerebral peptidergic caudodorsal cells of the freshwater snail Lymnaea stagnalis control egg laying and egg-laying behaviour by releasing peptides into (1) the haemolymph, from neurohaemal axon terminals in the periphery of the cerebral commissure and (2) the intercellular space of the central nervous system, from...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90149-2
更新日期:1988-07-01 00:00:00
abstract::Oxytocin and vasopressin binding sites were localized and characterized by quantitative autoradiography on consecutive sections of Long-Evans rat forebrains and pituitary glands, incubated in the presence of 5 nM [3H]oxytocin or 5 nM [3H]vasopressin. In the forebrain, two types of neurohypophysial hormone binding site...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90143-1
更新日期:1988-07-01 00:00:00
abstract::Neuromedin U is a newly described regulatory peptide, found by radioimmunoassay in significant concentrations in both the brain and gut of the rat. The aim of the present study was to localize this peptide immunoreactivity to discrete structures of the gut and brain and to map its distribution using immunocytochemistr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90037-1
更新日期:1988-06-01 00:00:00
abstract::Microinjections of the neuroexcitatory substance L-glutamate, were made directly into various laminae of trigeminal nucleus caudalis to examine the influence of medullary dorsal horn neurons on the adrenal secretion of catecholamines in the anesthetized cat. Microinjections into the marginal layers (lamina I-II) or in...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90270-9
更新日期:1988-05-01 00:00:00
abstract::The purpose of the present study was to test the respective roles of the intrinsic neurons and of the catecholaminergic fibers in two behaviors elicited by electrical stimulation of the lateral hypothalamus, intracranial self-stimulation and the increase in locomotor activity produced by noncontingent stimulation. One...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90261-8
更新日期:1988-05-01 00:00:00
abstract::We have developed a specific radioimmunoassay for "cerebellin", a 16-amino acid peptide recently isolated from rat cerebellum. In both rat and guinea-pig, cerebellin-like immunoreactivity was highest in the cerebellum but was also present in high concentrations elsewhere in the central nervous system, especially in th...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90262-x
更新日期:1988-05-01 00:00:00
abstract::In situ hybridization was used to measure the levels of proenkephalin mRNA and prodynorphin mRNA in regions of rat striatum and nucleus accumbens. Chronic administration of haloperidol (2.4 mg/kg/day for 7 days) increased the levels of proenkephalin mRNA in both striatum and nucleus accumbens. In contrast, the levels ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90256-4
更新日期:1988-05-01 00:00:00
abstract::Using in vitro receptor autoradiographic techniques we have analysed the pre- and postnatal development of neurotensin receptors in the rat brain. Receptors were labeled with [3H] or [125I]neurotensin in mounted tissue sections from animals of ages gestational day 14 until the postnatal day 21 as well as young adult a...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90028-0
更新日期:1988-04-01 00:00:00
abstract::The rat brain was examined immunocytochemically for estrogen-dependent changes of oxytocin immunoreactivity at the light microscopical level. Ovariectomized rats were treated with subcutaneous silastic implants with estradiol, or empty implants as controls for 2 days (short term treatment). Another group of rats was i...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90022-x
更新日期:1988-04-01 00:00:00